Last updated: 05.10.22
| Drug | Manufacturer | Use | Patent Expiration | Annual Sales* |
| Cuvposa* | Merz | Severe Drooling | Generic | $25 |
| Vasostrict | Endo | High Blood Pressure | Generic | $825 |
| Alphagan P 0.15% | Allergan | Glaucoma | Generic | $33 |
| Restasis | Allergan | Dry Eyes | Generic | $2,547 |
| Selzentry | Pfizer | HIV | Generic | $75 |
| Revlimid#* | Celgene | Cancer | Generic | $9,690 |
| Vimpat tablets | UCB Pharma | Seizures | Generic | $1,795 |
| Zipsor* | Depomed | Pain/Inflammation | Generic | $20 |
| Combigan* | Allergan | Glaucoma | Generic | $534 |
| Velcade* | Millenium | Cancer | May 1 | $1,435 |
| Alimta | Lilly | Cancer | May 25 | $1,638 |
| Noxafil Susp | Merck | Fungal Infections | Jun. 1 | $23 |
| Viibryd* | Allergan | Depression | Jun. 4 | $602 |
| Abraxane* | Abraxis | Cancer | 2Q2022 | $1,284 |
| Pradaxa* | BI | Anticoagulant | 2Q2022 | $523 |
| Iressa* | AstraZeneca | Cancer | Jul. 13 | $8 |
| Kinevac | Bracco | Gastrointestinal Diagnostics | Aug. 16 | $20 |
| Suprep Bowel Kit* | BI | Colon Preparation | Sep. 1 | $292 |
| Toviaz* | Pfizer | Urinary Incontinence | Oct. 1 | $236 |
| Folotyn* | Allos | Cancer | Nov. 15 | $38 |
| Xofigo | Bayer | Cancer | Nov. 17 | $15 |
| Treanda Powder* | Cephalon | Cancer | Dec. 7 | $68 |
| Rayos* | Horizon | Inflammation | Dec. 23 | $130 |
| Balcoltra | Avion | Contraceptive | 2022 | $62 |
| Flovent HFA | GSK | Asthma | 2022 | $1,971 |
| Forteo* | Lilly | Osteoporosis | 2022 | $747 |
| Neupro | UCB | Parkinson’s Disease | 2022 | $153 |
| Onexton Gel* | Valeant | Acne | 2022 | $124 |
| Oxaydo* | Egalet | Pain/Inflammation | 2022 | $10 |
| Thalomid* | Celgene | Cancer | 2022 | $30 |
| Zioptan* | Merck | Glaucoma | 2022 | $42 |
^Millions (IQVA sales [2021]); Generic = Generic available
*Settlement Agreement; #Limited supplies of generic through 2026
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